Abstract 12796: Obesity in Young Men and Long-term Risk of Atrial Fibrillation: 33-Year Follow-up of 12,850 Young Healthy Men
Background: The association between body mass index (BMI) measured in young adulthood and long-term risk of atrial fibrillation has been examined for women, but not men. We examined the association between BMI in young men and the risk of atrial fibrillation before 55 years of age.
Methods: We conducted a population-based cohort study of 12,850 males whose fitness for military service was examined by Draft Boards in Northern Denmark. Hospital diagnoses were obtained from the Danish National Registry of Patients, covering all Danish hospitals since 1977. We began follow-up on the 22nd birthday of each subject and continued until occurrence of atrial fibrillation, emigration, death, or 31 December 2010, whichever came first. Adjusting for cognitive score, education, and body height, we used Cox regression to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) associating BMI with atrial fibrillation occurrence.
Results: The cohort consisted of 10,639 (83%) men of normal weight (BMI: 18.5 to ≤25.0 kg/m2), 617 (5%) underweight men (BMI: ≤18.5 kg/m2), 1,368 (11%) overweight men (BMI: 25.0 to ≤30.0 kg/m2), and 226 (2%) obese men (BMI: ≥30 kg/m2). The cohort contributed a total of 352,582 person-years of follow-up and mean follow-up time was 28 years. The number of patients developing atrial fibrillation was 125 among normal weight men, 8 among underweight men, 29 among overweight men, and 5 among obese men. The corresponding 33-year risk of atrial fibrillation was 2.5% (95% CI: 1.2%-3.9%) for normal weight men, 2.9% (95% CI: 0.8%-5.1%) for underweight men, 4.0% (95% CI: 2.2%-5.8%) for overweight men, and 4.2% (95% CI: 1.1%-7.4%) for obese men. With normal weight as reference, the adjusted HR for atrial fibrillation was 1.04 (0.51-2.12) for underweight men, 1.90 (1.27-2.86) for overweight men, and 2.05 (95% CI: 0.84-5.03) for obese men. In a linear regression model, the adjusted HR associating one unit increase in BMI with atrial fibrillation was 1.10 (1.05-1.15).
Conclusions: Overweight and obesity in early adulthood strongly predicts atrial fibrillation before 55 years of age among men.
- © 2013 by American Heart Association, Inc.