Abstract 12787: Left Atrial Function Evaluated by 2D Speckle Tracking Imaging in Patients with Hypertension and Preserved Left Ventricular Ejection Fraction
Background: Two-dimensional (2D) speckle tracking echocardiography (STE) is a new tool for the evaluation of left atrial (LA) function. We aimed to assess LA myocardial function using 2D-STE in patients with hypertension and preserved LV ejection fraction (EF), and to explore the relationship between LA function and LV remodeling.
Methods: Routine 2D echocardiographic (frame rate of 45 ± 10 Hz, by ECG gating over 3 cardiac cycles) data were acquired using the GE Vivid 7 system in 103 hypertensive patients (54 men, age 53±10 years, blood pressure 146±23/89±9 mmHg) and 103 age- and gender-matched normotensive subjects (54 men, age 53±11 years, blood pressure 118±6/74±6 mmHg). The LA STE curves were obtained using the R-wave onset of electrocardiogram (ECG) as the reference point. We measured pre-atrial contraction volume (VpreA) at the P-wave onset of ECG, minimal LA volume (Vmin) at the closure of the mitral valve at end-diastole and maximal LA volume (Vmax) immediately before the opening of the mitral valve at end-systole, and then LA EF (Vmax-Vmin) and passive (Vmax-VpreA) and active empty EF (VpreA-Vmin) were calculated. The LA strain (εs, εa and εe=εs-εa) and velocity (Vs, Ve and Va) during systole ,early and late diastole were analyzed by the use of GE EchoPAC.
Results: The global LA εs, εe, εa,Vs, Ve and Va were significantly lower in hypertensive patients than normotensive subjects. The LA volume was significantly larger, and the empty EF were significantly lower in hypertension than normotension (Table). The global LA εs and Vmax were significantly correlated with LV mass index (r=0.30 and 0.36, respectively, P≤0.0001 for both).
Conclusions: Our results indicate that in hypertension LA volume increases and LA function decreases, and the latter is related with LV remodeling. The LA deformation parameters can probably be used in the clinical setting.
- © 2013 by American Heart Association, Inc.