Abstract 12737: Cardiac Early Diastolic Dys-Synchronyis Related to Left Ventricular Remodeling and Function in Hypertension
Background: Cardiac synchronization is important in maintaining myocardial performance. The mechanism of dys-synchronization in ailing to failing myocardium is unclear. The aim of this study is to investigate the related factors of diastolic dys-synchrony, which might be as a possible mechanism contributing to diastolic dysfunction in hypertension.
Methods: Simultaneous 2D and 3D (frame rate of 35 ± 10 Hz by ECG gating over 4 cardiac cycles) imaging data were acquired using the GE Vivid E9 system in 104 hypertensive patients (60 men, mean age 51±13years, blood pressure 169±25/100±17 mmHg) and 104 age- and gender-matched normotensive subjects (118±6/74±6 mmHg). The relative wall thickness (RWT) was calculated as the sum of ant-septal and posterior wall thickness divided by the LV end diastolic dimension. Analysis of 3D strain was performed with automated software allowing manual adjustment for myocardial borders detection. The LV mass index and EF were obtained from 3D analysis. The LV systolic and diastolic dys-synchrony indices were determined as the standard deviation of the time interval from the peak R of QRS complex to peak myocardial systolic strain rate (Ts-SD), to early diastolic strain rate (Te-SD) and to late diastolic strain rate (Ta-SD) of 12 LV segments.
Results: The mean values of LV RWT, mass index, and Te-SD were significantly higher in hypertension than normotension, but were not significantly different in Ts-SD and Te-SD between the two groups. In multiple linear regression, Te-SD as a single variable was associated with RWT, LV mass, E/E’, and systolic and diastolic pressure (table), but no association was observed between LV remodeling indices and Ts-SD or Ta-SD (r = -0.03 to -0.10, P>0.1).
Conclusion: The LV early diastolic dys-synchrony index was related to LV remodeling indices and diastolic dysfunction. These findings suggest that LV early diastolic dys-synchronization may be attributable to increased LV mass and may lead to diastolic dysfunction.
- © 2013 by American Heart Association, Inc.