Abstract 12693: Psoriasis Patients Have Greater Coronary Artery Disease Burden as Directly Assessed by Coronary Angiography
Psoriasis (PsA) may be associated with an increased risk of myocardial infarction and cardiovascular mortality. No prior study has systematically examined the extent and severity of coronary artery disease (CAD) among patients with PsA.
A retrospective analysis was performed on 65 patients with PsA (mean length of diagnosis prior to angiography = 13.8 years) and CAD who underwent coronary angiography from 2006-2011 at our institution. Age- and gender- matched patients without PsA were also identified. Previously validated scoring methods (Extent and Gensini) were used to assess the extent of CAD. The Extent score assesses the number of coronary segments with any significant CAD, while the Gensini score integrates disease extent and stenosis severity. A cardiologist blinded to the patient’s clinical status performed scoring.
Table 1 depicts the baseline demographics. Non-PsA patients had higher serum creatinine levels (1.7 ± 1.7 vs 1.1 ± 0.5 mg/dL, p = 0.02) but other risk factors and laboratory values were similar. PsA patients had greater extent of CAD burden as assessed by Extent (mean extent score 25.0 +/- 15.0 vs. 16.4 +/- 12.9, p=0.001) and Gensini scores (mean Gensini score 88.6 vs. 48.4, p=0.003).
Patients with PsA and CAD have significantly increased extent and severity of CAD compared to age- and gender-matched controls suggesting chronic inflammation in PsA may predispose to more diffuse CAD. Further studies are needed with direct intravascular imaging of CAD burden in patients with psoriasis; whether these findings translate into adverse long-term cardiovascular outcomes remains to be determined.
- © 2013 by American Heart Association, Inc.