Abstract 12575: High Dietary Phosphorus Intake is Associated With All-Cause Mortality: Results From NHANES III
Importance: Elevated serum phosphorus is associated with cardiovascular events and all-cause mortality, but little is known about the risk associated with dietary phosphorus intake.
Objective: To determine whether high dietary phosphorus intake is associated with mortality.
Setting: A representative sample of the U.S. non-institutionalized civilian population using the National Health and Nutrition Examination Survey (NHANES III, 1988-1994).
Participants: 9686 non-pregnant adults ages 20-80 without a history of diabetes, kidney disease (eGFR≤60ml/min/1.73m2), cardiovascular disease, or cancer.
Exposure: Dietary phosphorus intake assessed by 24-hour dietary recall.
Main Outcomes: All-cause and cardiovascular mortality (determined from death certificate data from the National Death Index) assessed through December 31, 2006.
Results: Individuals consuming more phosphorus were younger, more physically active, and more often male. In analyses adjusted for traditional cardiovascular risk factors, socioeconomic status, kidney function, vitamin D level, and total energy intake, risk for mortality was similar in the lower 4 quintiles of dietary phosphorus intake. Consuming the highest quintile (≥ 1739mg/d) of phosphorus intake was associated with increased all-cause mortality (adjusted hazard ratio (aHR) 1.36; 95% CI: 1.08-1.71) but not cardiovascular mortality (aHR 1.04; 95% CI: 0.69-1.55).
Conclusion: High phosphorus intake is associated with increased all-cause but not cardiovascular mortality in a healthy U.S. population. Future studies are needed to understand the mechanisms driving this increased mortality risk.
- © 2013 by American Heart Association, Inc.