Abstract 12521: Release Kinetics of Early Ischemic Biomarkers in Patients With Acute Myocardial Infarction
Background: Different biomarkers of myocardial ischemia have potential as novel early ischemic biomarkers in patients with acute coronary syndrome. The aim of this study was to determine the release kinetics of such biomarkers in patients with acute myocardial necrosis induced by transcoronary ablation of septal hypertrophy (TASH).
Methods: We analysed the release kinetics of soluble fms-like tyrosine kinase (sFlt-1), ischemia-modified albumin (IMA), and heart-type fatty acid-binding protein (hFABP) in consecutive patients (n=21) undergoing TASH for hypertrophic obstructive cardiomyopathy, a procedure that mimics the conditions present during AMI. Blood samples were collected prior to TASH and 15, 30, 45, 60, 75, 90, and 105 minutes and 2, 4, 8, and 24 h after TASH. sFlt-1 and hFABP were quantified in serum, and IMA was quantified in plasma using immunoassays.
Results: The values of sFLT-1 and hFABP increased significantly 15 min after induction of AMI vs. baseline as follows: sFlt-1, 3657.5 ng/L [IQR 2302.3-4475.0] vs. 76.0 ng/L [IQR 71.2-88.8] (P≤0.001); hFABP, 9.0 ng/mL [IQR 7.0-15.4] vs. 4.6 ng/mL [IQR 3.4-7.1] (P≤0.001). The IMA concentrations increased significantly 30 min after induction of AMI vs. baseline, with values of 26.0 U/mL [IQR 21.8-38.6] vs. 15.6 U/mL [IQR 10.1-24.7] (P=0.02).
Conclusions: sFlt-1 and hFABP concentrations increased very early after induction of myocardial ischemia in patients undergoing TASH, while IMA provided no additional information.
- © 2013 by American Heart Association, Inc.