Abstract 12512: Right Ventricular Early Diastolic Strain Rate is Associated With Plasma Brain Natriuretic Peptide Levels in Patients With Pulmonary Hypertension: Assessment by Two-Dimensional Speckle Tracking Imaging
Background: Right heart failure and the elevation of plasma brain natriuretic peptide (BNP) level are prognostic factors in patients with pulmonary hypertension (PH). We assessed the hypothesis that right ventricular (RV) diastolic dysfunction was correlated with symptom and plasma BNP levels in PH patients.
Methods: We performed transthoracic echocardiographic examination in 33 patients with PH (mean age: 60±17, mean pulmonary artery pressure: 38±11mmHg, 6 idiopathic pulmonary artery hypertension, 12 pulmonary arterial hypertension associated with connective tissue disease and 15 chronic thromboembolic pulmonary hypertension) and 20 age-matched controls. We measured global and 6 segments regional RV longitudinal strain (LS) and strain rate (LSR) in 4 chamber view using two-dimensional speckle tracking imaging. Peak systolic SR (LSR-S), peak early diastolic SR (LSR-E), and peak late diastolic (LSR-A) were analyzed in global RV and each segments. Then, we compared those LS and LSR parameters with WHO functional classification and the log-transformed BNP (log BNP) values.
Results: Both global LSR-E and RV mid free wall LSR-E in PH patients were decreased significantly compared with those in normal controls. (global LSR-E: p≤0.001, RV mid free wall LSR-E: p≤0.001). In PH group, global LSR-E and RV mid free wall LSR-E were correlated with WHO functional classification and log BNP, respectively.(global LSR-E: p=0.006, r=-0.47, RV mid free wall LSR-E: p=0.02, r=-0.39)
Conclusions: 2D speckle tracking analysis showed that global and regional early diastolic strain rate were associated with symptom and plasma BNP levels in patients with PH. These results suggested that it would be valuable to evaluate not only RV systolic function but diastolic function in PH patients.
- © 2013 by American Heart Association, Inc.