Abstract 12443: Increased Volume of Epicardial Fat is an Independent Risk Factor for the Severity of Coronary Artery Disease in Patients With Preserved Ejection Fraction
Background: Metabolic syndrome (MetS) and Visceral fat obesity are associated with the increasing risk of ischemic heart disease (IHD). Thus, we assessed the relationship between the epicardial fat volume (EFV) and the characteristics of coronary plaques in patients with IHD, using 64-Multi Detector Computed Tomography (MDCT).
Method: We quantified body surface area indexed-EFV values (EFVi, ml/m2), and determined the severity of coronary stenosis in patients who underwent coronary angiography. Consecutive 104 patients (mean age, 68±10) with IHD were categorized to tertiles of EFVi: low tertile, EFVi≤81.2ml/m2; mid-tertile, 81.2ml/m2≦EFVi≦114 ml/m2 ; high tertile, EFVi>114 ml/m2. We evaluated the body mass index (BMI), waist circumstances, the Gensini score (GS), and the coronary plaque component.
Results: Plaques with spotty calcification were more frequent in group high EFVi compared to group low EFVi (p≤0.05). GS was significantly different between the 2 groups (high EFVi and low EFVi), indicating a stepwise decrease in GS from high EFVi to mid-EFVi and to low EFVi. EFVi had a significant positive correlation with BMI (p≤0.0043). GS had a significant positive correlation with EFVi (p≤0.0001). However, no significant association was found between GS and BMI. In multivariate analysis, high EFVi remained an independent predictor for patients with the coronary severity (p= 0.04) than the BMI, and waist circumstances.
Conclusion: Patients with high EFVi have more epicardial fat volume and vulnerable plaques, and the characters of coronary lesions were more severe. The uneven distribution of epicardial fat might be more highly associated with the progression of IHD.
- © 2013 by American Heart Association, Inc.