Abstract 12400: Significant Association between Decreased Plasma Levels of Brain-derived Neurotrophic Factor in Heart Failure
Background: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, which regulates neuronal differentiation and functions. The decreased levels of BDNF are caused by the expose to mental stress and potentially play a role in the pathogenesis of depression and cognition disorder. It is reported that BDNF enhances angiomyogenesis and has cardioprotective effect after myocardial infraction. Because psychical stress and depression are associated with an increased risk of heart failure (HF), the pathogenic link between heart failure and mental status have attracted great clinical attention. We hypothesized that plasma BDNF levels might be decreased in patients with HF and BDNF could be a key factor associated with HF.
Method and results: We evaluated plasma BDNF levels by enzyme-linked immunosorbent assay in 152 HF patients [age 69.7±12.0 y.o, male: 63.8%, left ventricular ejection fraction (LVEF): 42.8±13.0%, New York Heart Association (NYHA) classification; I (n=18), II (n=85), III (n=49)] and 72 age- and gender-matched non-HF subjects. Plasma BDNF levels in HF patients were significantly lower than those in non-HF patients (3280 [1824 to 5104] vs. 7139 [5206 to 9220] pg/ml; p≤0.001). Log-transformed plasma BDNF levels (logBDNF) were significantly lower in patients in NYHA class III than those in NYHA class I and II (p=0.005), and non-HF subjects (p≤0.001). Among HF patients, logBDNF levels were negatively correlated with log-transformed B-type natriuretic peptide (r= -0.203, p=0.01). Plasma BDNF levels did not differ between ischemic and non-ischemic etiology (p=0.49), and preserved and reduced LVEF (p=0.90). Among various clinical factors including LVEF and estimated glomerular filtration rate, multivariate logistic regression analysis identified the logBDNF levels (per 0.1) was significantly correlated with the presence of HF (odds ratio 0.78, 95% confidence interval 0.68 to 0.90, p ≤0.001).
Conclusions: Plasma levels of BDNF were significantly decreased in HF patients. Decreased levels of BDNF might reflect not only psychical stress but also HF severity in HF patients. BDNF could be a clinically correlated biomarker with HF reflecting the possible cardio-neuronal linkage.
- © 2013 by American Heart Association, Inc.