Abstract 12367: Adventitial Vasa Vasorum in Patients With Native Atherosclerosis Compared to Post-Transplant using 3D Coronary Optical Coherence Tomography
Backgrounds: The vasa vasorum (VV) play an important role in the progression and complications of native atherosclerosis and potentially allograft vasculopathy. In this study, we have compared the association of adventitial VV with vascular remodeling in patients with native atherosclerosis (NA) and transplant (Tx) vasculopathy using 3D reconstructed images of coronary optical coherence tomography (OCT).
Methods and Results: Each group included 5 patients (Male/Female 5/5, Age 24 - 66 yo) who were referred to coronary angiography. OCT imaging was performed in left anterior descending artery with C7-XR system (St. Jude Medical, St. Paul, MN), and recorded over 50 mm divided into 5 ten-mm-segments. In a total of 29 segments (N=16 NA; N=13 Tx), we defined low intensity areas with diameters between 50-300 micrometer as adventitial VV, which were traced manually in all slices, as were the lumen-intima and media-adventitia boundaries. 3D images were reconstructed using the ANALYZE software 11.0 (Biomedical Imaging Resource, Rochester, Minnesota) (Figure. A): Subsequently, the cumulative volume of VV and the plaque volume(PV) were calculated in each segment. PV were calculated by subtracting lumen volume from vessel volume. Average VV volume in NA were greater than in Tx (VV 1.74±0.70 vs. 1.15±0.53 mm3, P=0.019; PV 23.7±8.2 vs. 19.3±6.8 mm3, P=0.133). Both groups showed significant correlations between VV volume and PV (Figure. B ). The ratio of VV to PV in the NA group was significantly greater than in Tx group (7.7 x 10-2 ± 2.9 x 10-2 vs. 5.8 x 10-2 ± 1.7 x 10-2, P=0.041).
Conclusion: adventitial VV volume is significantly correlated with PV in both NA and Tx, but the VV-PV ratio was different between two groups, suggesting that VV might play different roles in evolution of vasculopathy in native atherosclerosis compared to transplant patients.
- © 2013 by American Heart Association, Inc.