Abstract 12349: 5 - Year Mortality in Patients With Left Ventricular Diastolic Dysfunction and Preserved Ejection Fraction
Background: Left ventricular diastolic dysfunction (DD) is an independent predictor of mortality in patients with preserved left ventricular ejection fraction. However, there is limited data on whether severity of DD is associated with worse prognosis.
Methods: We reviewed demographic, clinical and echocardiographic records of consecutive 911 patients who underwent echocardiogram that revealed preserved ejection fraction (≥50%) from December 1, 2007 to December 31, 2008. Diastolic function was labeled as normal, mild (grade 1: impaired relaxation), moderate (grade 2: pseudonormal), or severe (grade 3: restrictive) dysfunction. All-cause mortality was determined by use of the Social Security Death Index. Kaplan-Meier survival analysis and Cox regression analysis with a proportional hazard model were performed to assess outcomes.
Results: Total 911 patients were included in the study and were followed for 60 months. DD was present in 661 patients (72.5%). In the follow up period, 285 deaths (31.3%) occurred. Mortality rate was worse in the group with DD (p = 0.046). Cox Regression analysis revealed that grade 2 and 3 (moderate and severe) DD were associated with increased mortality (HR = 1.363; CI = 1.001 - 1.857; p = 0.049, and HR = 2.416; CI =1.075 - 5.434; p = 0.033, respectively).
CONCLUSIONS: In the present study, moderate and severe DD with preserved ejection fraction were associated with worsened 5-year all-cause mortality. Mortality was worse when DD was more severe. Mild DD had no significant impact on survival.
- © 2013 by American Heart Association, Inc.