Abstract 12314: Impairment of Right Ventricular Function Using 2D and 3D Global Longitudinal Strain of the Right Ventricle on Transthoracic Echocardiography Differentiates Hypertrophic Cardiomyopathy From Controls
Purpose: We evaluated the use of two (2D) and three-dimensional (3D) global longitudinal strain (GLS) of the right ventricle (RV) using transthoracic echocardiography (TTE) to differentiate hypertrophic cardiomyopathy (HCM) from controls.
Materials and Methods: A total of 34 subjects (22 HCM (16 male; mean age, 68 ± 8 years) and 12 controls (5 male; mean age, 60 ± 22 years) underwent TTE (Vivid E9, GE Healthcare) to measure 2D and 3D GLS of the RV and left ventricle (LV) using ECHOPAC and TOMTEC software and other TTE parameters.
Results: Wall thickness of the interventricular septum (IVS), LV posterior wall thickness on end-diastole, and left atrial volume were significantly greater in HCM subjects than controls. There were no significant differences of traditional RV parameters (estimated systolic pulmonary arterial pressure, tricuspid annular plane systolic excursion, fractional area change) between HCM and controls. Absolute values of 2D and 3D GLS of RV and LV were significantly lower in HCM subjects than controls (13.1 ± 4.7% vs 24.0 ± 2.9% P ≤ 0.001 (2D GLS whole RV), 17.0 ± 8.1% vs 28.4 ± 3.1% P ≤ 0.001 (2D GLS only RV free wall not including IVS), 9.9 ± 2.7% vs 17.9 ± 3.0%, P ≤ 0.001 (2D GLS LV), 11.5 ± 4.7% vs 19.4 ± 5.7%, P ≤ 0.001 (3D GLS whole RV), 11.2 ± 6.3% vs 19.3 ± 7.4%, P ≤ 0.001 (3D GLS only RV free wall not including IVS), 8.2 ± 3.4% vs 14.6 ± 2.9% P ≤ 0.001 (3D GLS LV), respectively. However, there were no significant differences of 3D end diastolic and systolic volume or ejection fraction of both the RV and LV between HCM and controls.
Conclusions: 2D and 3D GLS of both whole RV and only the RV free wall not including IVS using TTE differentiates HCM subjects from controls, as well as 2D and 3D GLS of the LV. In spite of the lack of significant differences of traditional RV parameters and 3D volume and ejection fraction of both the RV and LV on TTE between HCM and controls, impairment of global RV function such as 2D and 3D GLD of the RV might occur in HCM subjects, which is different from controls.
- © 2013 by American Heart Association, Inc.