Abstract 12313: Association Between Serum Cystatin C Level and Cardiometabolic Risk Factors Among Japanese Junior High School Students
Background: Serum cystatin C is a novel and sensitive marker of renal function. Recent studies have suggested that cystatin C level is also significantly related to the components of metabolic syndrome in adults. We examined whether cystatin C level might be associated with cardiometabolic risk factors using a school-based sample of Japanese junior high school students.
Methods: Between April 2010 and March 2012, we conducted a cross-sectional study of 379 Japanese junior high school students (180 boys and 199 girls, aged 12.1 to 15.0 years) who had annual school health examinations and received care programs for prevention of lifestyle-related diseases. The students underwent measurements of resting blood pressure, waist circumference, and weight and provided overnight fasting venous blood samples for laboratory analyses. Serum cystatin C level was measured by using a particle-enhanced immunonephelometric assay.
Results: Cystatin C level was averaged 0.84 ± 0.12 mg/L. In boys, average cystatin C level was 0.92 ± 0.10mg/L, which was significantly higher than that in girls (0.77 ± 0.08mg/ L), and was significantly correlated with serum uric acid (SUA) (r = 0.34, P ≤0.001) and blood urea nitrogen (r = 0.24, P ≤0.001). In girls, there was a significant correlation between cystatin C level and SUA (r = 0.28, P ≤0.001). Multivariate regression analysis revealed an association between cystatin C level and SUA among all subjects (β = 0.26, P ≤0.001 with adjustment for sex, systolic and diastolic blood pressure, high sensitivity CRP, high-density lipoprotein cholesterol, triglyceride), also in both genders (β = 0.34, P ≤0.001 in boys and β = 0.31, P ≤0.001 in girls, respectively).
Conclusions: Serum cystatin C level was strongly associated with SUA, which is a marker of renal dysfunction as well as elevated insulin resistance, among Japanese junior high school students. Further longitudinal studies are warranted to determine the role of cystatin C in future cardiovascular disease risk and progression.
- © 2013 by American Heart Association, Inc.