Abstract 12308: Non-Cardiac Death in Acute Decompensated Heart Failure: From ATTEND Registry
Background: The mortality of acute decompensated heart failure (ADHF) is still relatively high. ADHF patients commonly have multiple co-morbidities and the cause of death in these patients is not always aggravated heart failure. Previous pivotal studies did not address clinical importance of non-cardiac death in ADHF. The present study was therefore conducted to assess the incidence and predictors of non-cardiac mortality in ADHF patients from the Acute Decompensated Heart Failure Syndromes (ATTEND) Registry.
Methods: The ATTEND registry was a nationwide, prospective observational multicenter cohort study in 52 hospitals across Japan. The registry included 4,842 consecutive ADHF patients from April 2007 to September 2011. The primary endpoint was non-cardiac death in hospital. All variables were entered into the statistic model to identify predictors of the primary endpoint.
Results: Total in-hospital mortality was 312 cases (6.4%), cardiac death (n=219, 4.5%) and non-cardiac death (n=93, 1.9%) among 4,842 ADHF patients. The details are shown in the figure and the predictors of non-cardiac mortality are shown in the table.
Conclusion: 30% of in-hospital mortality in ADHF patients was due to non-cardiac causes. Therefore prevention of non-cardiac complications and a more comprehensive care package is required for ADHF patients with the identified predictors of non-cardiac death.
- © 2013 by American Heart Association, Inc.