Abstract 12301: Stretching Exercises Attenuate Oxidative Stress and Vascular Endothelial Function in Heart Failure Patients With Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy-Defibrillator
Introduction: Although an aerobic exercise reduces oxidative stress and improve vascular endothelial dysfunction, patients with implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) hesitate to perform aerobic exercise because of the anxiety to increasing physical activity. A single session of stretching exercises was reported to enhance vascular endothelial function in patients with acute myocardial infarction. The aim of this study was to evaluate the effects of 4-week stretching exercises on oxidative stress and vascular endothelial function in heart failure (HF) patients with ICD or CRT-D.
Methods: Thirty four sedentary HF patients who had been implanted with ICD or CRT-D and whose mean age and left ventricular ejection fraction were 70.3±8.1 years and 29.7±8.1 %, respectively, were randomly divided into two groups. Seventeen patients performed the stretching exercises (stretching group) and the other 17 continued the sedentary lifestyle (control group). Stretching exercises consisted of seven movements including trunk rotation, cross-legged trunk flexion and ankle dorsiflexion, and were performed in 20 minutes once a day for 4 weeks. We measured a reactive hyperemia index (RHI) and serum von Willebrand factor (vWF) as parameters of vascular endothelial function, and serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) and reactive oxygen species (ROS) as parameters of oxidative stress. We compared these parameters before and after the exercise period, and between the two groups.
Results: The RHI, vWF, MDA-LDL and ROS showed no significant changes before and after the exercise period in the control group. In the stretching group, the RHI increased significantly, and the vWF, MDA-LDL and ROS decreased significantly after the exercise period as compared to those before (P≤0.01, P≤0.05, P≤0.05 and P≤0.01, respectively). After the exercise period, the RHI was significantly higher and the ROS was significantly lower in the stretching group than in the control group (P≤0.05 and P≤0.05, respectively).
Conclusion: This study demonstrated that 4-week stretching exercises attenuated oxidative stress and improved vascular endothelial dysfunction in HF patients with ICD or CRT-D.
- © 2013 by American Heart Association, Inc.