Abstract 12276: Post-Resuscitation Treatment With Argon Improves Neurological Outcome in a Porcine Model of Myocardial Infarction and Cardiac Arrest
Introduction: Effects of post-resuscitation treatment with argon on neurological recovery was investigated in a porcine model of cardiac arrest (CA) with an underlying acute myocardial infarction.
Methods: The left anterior descending coronary artery (LAD) was occluded by a balloon catheter in 12 pigs and CA was induced. After 8 min of untreated CA, cardiopulmonary resuscitation was performed for 5 min prior to defibrillation. Following resuscitation, animals were subjected to 4 hr ventilation with: 70% argon/30% oxygen; or 70% nitrogen/30% oxygen. Myocardial function was echocardiographically assessed. Blood samples were obtained for blood gas, serum neuron specific enolase (NSE) and plasma high sensitive cardiac troponin T (hs-cTnT) assays. Animals were observed up to 72 hr for assessment of survival and neurological recovery. At sacrifice, heart and brain were harvested.
Results: All the animals were resuscitated and survived for 72 hr, except for a control pig. Ventilation with argon did not have any detrimental effects on hemodynamics and respiratory gas exchange. All the argon treated animals had a fast and complete neurological recovery, in contrast to controls, in which neurological impairments persisted (p ≤ 0.01, Figure). Accordingly, there were also significantly lower increases in serum NSE and minimal histological brain injury in argon treated animals, in comparison to controls.
Conclusions: Post-resuscitation treatment with argon may be an important clinical option for neuroprotection after CA.
- © 2013 by American Heart Association, Inc.