Abstract 12138: Is Skin to Right Ventricle Distance on Echo Similar to Anthropometric Measurements in Its Association With Systemic Inflammation?
Background: Obesity and visceral fat are associated with increased levels of inflammatory biomarkers. We previously reported that echo parasternal long axis measurements of the maximal end-systolic anterior visceral pericardial fat (PF) and skin to RV distance (SkRV) are independently associated with anthropometric measures (AMs), age, race, and gender. The relationship of these echo measurements to biomarkers has not been previously described.
Method: We measured body mass index (BMI) and waist circumference (WC) in 150 patients (mean age 46.5 ± 10.6 years; 57% female, 68% black, mean body mass index 32.5 ± 8) who presented to our clinical decision unit with chest pain and no history of coronary artery disease. Clinical risk factors were recorded. SkRV and PF were measured on echo. Serum biomarkers associated with systemic inflammation were measured (Siemens, Tarrytown, NY). Pearson correlation coefficients and multiple regression analysis were used to assess the association between biomarkers and SKRV and PF.
Results: Table 1 lists Pearson correlations between inflammatory biomarkers and AMs, SkRV, and PF. In separate multiple regression analysis, after adjusting for age, gender and race, PF and SkRV were independently associated with each biomarker. There was no significant association between biomarkers and SkRV when BMI or WC was added to the models. For pericardial fat, however, tumor necrosis factor-alpha remained associated after the addition of either BMI or WC.
Conclusion: Similar to BMI and WC, both SkRV and PF are associated with markers of systemic inflammation, independent of age, gender, and race. The disappearance of most associations when adjusted for either BMI or WC suggests that SkRV and PF may be ultrasound equivalents to traditional anthropometric measures of obesity.
- © 2013 by American Heart Association, Inc.