Abstract 12082: Clinical Impact of 18f-fdg-pet/ct in Patients With Infective Endocarditis
Objective: Infective endocarditis (IE) is a serious condition with significant mortality. Besides the degree of valve pathology, the prognosis relies crucially on the presence of systemic infectious embolization. The purpose of this study was to assess the clinical impact of 18F-FDG-PET/CT used in the work-up of patients with IE.
Methods: 72 patients (71 % males, mean age 63 ± 17 years) with IE were evaluated with 18F-FDG-PET/CT in addition to standard work-up including patient history, physical examination, conventional imaging modalities and weekly interdisciplinary conferences. When lesions detected by 18F-FDG-PET/CT were confirmed by succeeding examinations, they were considered true positive and were further assessed for their clinical relevance. Numbers Needed to Investigate was calculated as the number of patients needed to undergo 18F-FDG-PET/CT to find at least one clinical relevant true positive finding, not identified by standard work-up.
Results: 18F-FDG-PET/CT detected 114 lesions and 64 were true positive of which 25 were not detected by the standard work-up. Among these 14 were considered to have a considerably prognostic impact; osteomyelitis (n=8), iliopsoas abscess (n=1), gastrointestinal foci (n=4), vascular prostethic graft (n=2) and a respiratory polyp (n=1). Numbers Needed to Investigate was 5 (14 of 72 patients).
Conclusion: 18F-FDG-PET/CT detected lesions of significant importance in one of five patients and may be an important imaging technique for tracing peripheral infective embolism due to IE. Thus 18F-FDG-PET/CT may improve the prognosis of patients with IE.
- © 2013 by American Heart Association, Inc.