Abstract 12064: Electrocardiographic Variables are Strongly Associated With Ambulatory Hypertension in Young and Healthy Adults
Purpose: The aim of this study was to assess the association between several easily available electrocardiographic (ECG) variables and ambulatory hypertension in young and healthy adults.
Methods: We performed a population-based cross-sectional study of healthy adults aged between 25 and 41 years. Individuals with drug-treated hypertension, diabetes mellitus, a body mass index (BMI) >35kg/m2 and prevalent cardiovascular disease were excluded. Ambulatory 24-hour blood pressure (BP) was measured with a validated device (Schiller AG, Switzerland). Hypertension was defined as systolic daytime BP ≥140 and/or diastolic daytime BP ≥90mmHg, respectively. Standard 10 second 12-lead ECG was performed in all participants. The relationship between ECG variables and hypertension was assessed using multivariable logistic regression analysis.
Results: Of 749 participants, 128 (17.1%) had hypertension. Compared to normotensive individuals, hypertensive individuals were significantly older (40 vs. 38 years, p=0.008), more often male (80% vs. 20%, p≤0.0001) and they had a higher BMI (26 vs. 24 kg/m2, p≤0.0001). After adjustment for age, sex, BMI, cholesterol and smoking status, R wave amplitude in lead I and V6, and positive T wave amplitude in V2 and V5 were significantly related to prevalent hypertension, as shown in the Table. When these ECG variables were combined in a single multivariable model, all indices except for R wave amplitude in lead I remained statistically significant (Table). Discrimination for prevalent hypertension of this combined model was good with a C-statistic of 0.80.
Conclusion: We found that four easily available ECG indices were significantly associated with daytime hypertension on ambulatory BP measurement, independent of clinical variables. If the high C-statistic is confirmed in other studies, these indices may become a useful screening tool for ambulatory hypertension.
- © 2013 by American Heart Association, Inc.