Abstract 11984: Statins More Strongly Reduce Postprandial Triglyceride Levels in Patients With Greater Postprandial Triglyceride Increase
Objective: Increased serum triglyceride (TG) levels promote the production of small dense low-density lipoprotein (sdLDL). We examined effect of statins on day-long suppression of postprandial TG increase.
Methods: Ninety-eight patients with untreated dyslipidemia were administered atorvastatin, rosuvastatin, or pitavastatin. We analyzed serum TG levels before and after breakfast and before and after statin therapy. Diet-induced TG increase (ΔTG) was calculated as “postprandial TG - fasting TG”. Pre- and post-therapy ΔTG was defined as ΔTG[[Unable to Display Character: ]]base and ΔTG[[Unable to Display Character: ]]statin, respectively. ΔTG difference = ΔTG[[Unable to Display Character: ]]statin - ΔTG[[Unable to Display Character: ]]base was proposed as an indicator of statin therapy’s effects.
Results: Post-statin therapy, postprandial TG increase was significantly suppressed. Patients were then divided into effective (ΔTG difference ≤ 0; n = 57) and non-effective (ΔTG difference ≥ 0; n = 41) groups. In the effective group, ΔTG[[Unable to Display Character: ]]base was significantly greater (84.1 ± 63.7 mg/dL vs. 17.4 ± 42.6 mg/dL, p ≤ 0.0001), ΔTG[[Unable to Display Character: ]]statin was significantly smaller (14.3 ± 42.7 mg/dL vs. 63.7 ± 46.0 mg/dL, p ≤ 0.0001), and ΔTG difference demonstrated a marked decrease (-69.8 ± 67.6 mg/dL vs. +46.3 ± 47.1 mg/dL, p ≤ 0.0001). Further, ΔTG difference showed a remarkable inverse correlation (R2 = 0.6302) with ΔTG[[Unable to Display Character: ]]base (Figure 1). Postprandial TG was significantly reduced, particularly in patients with excessive postprandial elevation (Figure 2).
Conclusion: Statins strongly suppressed diet-induced TG increase, particularly in patients with high TG increase, irrespective of fasting TG levels. Statins may benefit patients with high diet-induced TG increase, resulting in day-long sdLDL reduction.
- © 2013 by American Heart Association, Inc.