Abstract 11518: Atorvastatin Reduces Atherosclerotic Plaque Inflammation and Serum High-Sensitivity CRP Levels in Patients With Carotid Atherosclerosis
Statins have pleiotropic effects including anti-inflammatory property besides lipid-lowering; however, there was scarce visible evidence demonstrating such an effect in human atherosclerotic plaques. We therefore evaluated plaque inflammation in the carotid artery, thoracic and abdominal aorta by using 18fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) before and after atorvastatin treatment in patients with carotid atherosclerosis detected by ultrasonography.
Thirty-one statin-naïve patients were randomized to either a group receiving dietary management (n=15) or that receiving atorvastatin (10 mg/day) plus dietary management (n=16) for 3 months. 18FDG-PET/CT, endothelial function evaluated by flow-mediated vasodilation (FMD), and fasting blood sampling were performed. Atorvastatin, but not the diet-only treatment, significantly reduced LDL-cholesterol (-43%) and serum high-sensitivity CRP levels (-37%) and promoted FMD (+38%). Further, 18FDG-PET/CT revealed that atorvastatin significantly attenuated accumulation of 18FDG in carotid artery (-12%) and abdominal aorta (-8%), but not in thoracic aorta (Figures); whereas diet-only treatment did not affect these parameters.
In summary, atorvastatin treatment improved vascular inflammation visualized by 18FDG-PET as well as reduced CRP levels and promoted endothelial function within the relatively short period. These data therefore indicate that atorvastatin may exert additional cardio-protective effects through anti-inflammatory function.
- © 2013 by American Heart Association, Inc.