Abstract 11503: Gender Differences in Baseline Characteristics, Procedural Features and Outcome in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary PCI
The treatment of ST-segment elevation myocardial infarction (STEMI) has improved enormously since the shift from thrombolysis to primary percutaneous coronary intervention (pPCI). Whether gender differences in baseline characteristics, procedural features and outcome exist remains ambiguous. Therefore we systematically and comprehensively reviewed the available evidence.
Pubmed, Embase and Cochrane were searched for studies consisting original data on STEMI patients treated with pPCI on 10-05-2013. A separate gender analysis with more than 100 women should be present. Data on baseline profile, procedural characteristics and outcome were extracted.
In total 21 studies were eligible. At baseline women were older and had more frequently diabetes and hypertension while men more often smoked. Women were in a higher Killip Class at presentation. The symptom-to-balloon-time was longer in women than in men while the door-to-balloon-time was comparable. Women experienced a higher mortality at different points in time during follow-up. However after multivariate analysis there were no significant differences in outcome found between women and men. This led to the conclusion that the disadvantageous outcome is indeed present in women and caused by their unfavorable risk profile. Clinicians should be aware of this important finding and optimize treatment and prevention to counter this adverse outcome in women.
- © 2013 by American Heart Association, Inc.