Abstract 11485: Preadmission Statin Use is Associated With Lower Mortality After Rupture of Abdominal Aortic Aneurysm
Objective: Rupture of abdominal aortic aneurysms (rAAA) is associated with high mortality. Statins reduce risk of cardiovascular events and death and have also been associated with lower mortality in patients with severe sepsis, septic shock or trauma. Two small, single centre studies have suggested an association between statin therapy and lower mortality following haemorrhagic shock and rAAA. We examined the association between preadmission statin use and 30-day mortality after rAAA in a large nationwide, population-based study.
Methods: Using Danish population-based registries we conducted a follow-up study among all patients with an incident diagnosis of rAAA in Denmark from 1996 through 2008. We obtained data on all filled statin prescriptions prior to admission with rAAA. We estimated 30-day mortality rate ratios (MRRs) with 95% confidence intervals (CI) associated with current statin use, using Cox proportional hazards regression analysis. Results were adjusted for age, sex, comorbidity, concomitant drug use, calendar year and socioeconomic factors.
Results: We identified 4,761 rAAA patients, 586 (12.3%) of whom were current statin users. Statin users had substantially more comorbidity, in particular cardiovascular diseases. The aggregated 30-day mortality rate following rAAA among current statin users was 50.4%, as compared to 60.4% in statin non-users. The adjusted 30-day MRR for current statin users was 0.84 (95% CI: 0.73 to 0.97) corresponding to a 16% reduced risk of death. In contrast, patients who had formerly used statins (i.e., prescriptions more than 90 days ago) but had no current statin use did not have reduced mortality (adjusted MRR 0.95 (95% CI: 0.79 to 1.15)).
Conclusion: Preadmission statin use is associated with lower mortality after rAAA. These results support current international guidelines recommending statin therapy in patients diagnosed with abdominal aortic aneurysms.
- © 2013 by American Heart Association, Inc.