Abstract 11402: Relationship Between Uric Acid and Myocardial Damage in General Population
Background: Previous studies have revealed that serum uric acid levels are associated with wide variety cardiovascular conditions, including hypertension, metabolic syndrome, coronary artery disease, and kidney disease. Serum heart-type fatty acid-binding protein (H-FABP) has been recognized as a marker of cardiac acute and chronic myocyte injury. However, the association between uric acid and myocardial damage has been not clear in general people. Therefore, the purpose of this study was to elucidate whether uric acid associated with H-FABP as myocardial damage.
Methods and Results: We studied 2,390 normal subjects (mean age, 64 years; men, 1051; women, 1339) who received an annual health check-up in Takahata town. The latent myocardial damage in general people was defined as serum levels of H-FABP above 4.3 ng/mL as reported previously. Uric acid levels were significantly higher in subjects with latent myocardial damage than in those without it. Uric acid levels were significant positively correlated with H-FABP levels (r=0.166; p<0.0001). Serum H-FABP levels were affected by age, body mass index, estimated glomerular filtrating ratio, brain natriuretic peptide, and uric acid. Multivariate logistic analysis showed that uric acid levels were independently associated with the presence of latent myocardial damage further adjustment for those. (odds ratio: 1.263, 95% confidence interval 1.127-1.397, p<0.0001). Subjects were divided into 4 groups depending on uric acid levels (group 1: uric acid levels < 6.0 mg/dl, group 2: uric acid levels 6.1-7.0 mg/dl, group 3: uric acid levels 7.1-8.0 mg/dl, group 4: uric acid levels > 8.1mg/dl). In men, the latent myocardial damage was seen in group 3 and 4. On the other hand, in women, the latent myocardial damage was seen in group 2, 3 and 4.
Conclusion: Uric acid levels related to myocardial damage in general people. It is new to evaluate uric acid levels from the perspective of latent myocardial damage.
- © 2013 by American Heart Association, Inc.