Abstract 11377: Meeting the Physical Activity Guidelines and Risk of Cardiovascular Disease and Cancer Mortality: Cooper Center Longitudinal Study
Introduction: National cardiovascular and cancer organizations provide the same recommendations for physical activity: 150 minutes of moderate intensity or 75 minutes of vigorous intensity physical activity (PA) per week. However, it is unknown whether meeting the guidelines for PA is associated with similar protection against cardiovascular (CVD) and cancer death.
Methods: We studied 53,113 participants (average age 46y) in the Cooper Center Longitudinal Study (CCLS) who presented to the Cooper Clinic between 1987-2009 and provided detailed records of self-reported physical activity frequency, intensity, and duration. An estimate of total metabolic equivalent (MET)-minutes-week-1 was computed by multiplying the minutes by an estimated MET equivalent for each activity and summing across all activities. MET-minutes-wk-1 values were categorized into three groups based on the national guidelines for PA: not meeting guidelines (<500 MET-min-wk-1), meeting guidelines (500-999 MET-min-wk-1), or exceeding guidelines (≥1000 MET-min-wk-1). Cox proportional hazards were utilized to determine the relationship between PA and cancer and CVD mortality in age and sex adjusted models.
Results: During 693,634 person-years of follow-up (average follow-up 13y), there were 550 CVD and 857 cancer deaths, respectively. Compared to those not meeting the guidelines for PA, meeting or exceeding the guidelines was associated with a 25% (HR: 0.75 [95% CI:0.64, 0.89]) and 31% (HR: 0.69 [95% CI: 0.60, 0.79]) reduction in CVD mortality, respectively. In contrast, a 14% (HR: 0.86 [95% CI: 0.73,1.00]) and 10% (HR:0.90 [95% CI: 0.80,1.02]) relative risk reduction in cancer mortality was demonstrated for the same intensity and frequency of PA.
Conclusion: Meeting the guidelines for PA was associated with a significant reduction in CVD mortality, but not cancer mortality among CCLS men and women. Future studies are required to determine optimal PA requirements for overall and site-specific cancer prevention.
- © 2013 by American Heart Association, Inc.