Abstract 11201: Severe Obstructive Sleep Apnea is Associated With Higher All Cause Mortality After Percutaneous Coronary Intervention: A 4 Year Follow Up Study
Introduction: There is limited data regarding influence of obstructive sleep apnea (OSA) on mortality after percutaneous coronary intervention(PCI). The aim of this study was to assess outcomes of PCI in patients with OSA.
Methods: In a single center prospective PCI registry, we studied 356 patients who underwent PCI and had nocturnal polysomnography performed at our institution between ’01 and ’11. We assessed major adverse cardiovascular events (MACE) and all cause mortality in patients with severe OSA (S-OSA, defined as respiratory disturbance index (RDI) ≥ 30, N=163) in comparison to those with non severe OSA (NS-OSA, defined as RDI<30, N=193).
Results: The mean age of the patients studied was 61±11yrs. With the exception of body mass index, there were no significant differences in demographic, angiographic, clinical or procedural characteristics between the two study groups (table 1). At a mean follow up of 4.3±1.7yrs, all cause mortality occurred in 12.9% of S-OSA group as compared to 6.2% in the NS-OSA group. (P Value=0.031) (HR=2.1, 95% CI=1-4.3). There was no significant difference in the number of MACE. (29% Vs 28%, P Value=0.77) (table 2, figure 1).
Conclusions: Although the presence of severe OSA is not associated with increase in post PCI MACE, it is associated with higher all cause mortality.
- © 2013 by American Heart Association, Inc.