Abstract 11183: In-hospital Mortality in Patients With Connective Tissue Disease Presenting With Acute Myocardial Infarction
Objective: Premature coronary artery disease due to accelerated atherosclerosis is a leading cause of morbidity and mortality in patients with connective tissue disease (CTD). Particularly, patients with systemic lupus erythematous (SLE) and rheumatoid arthritis (RA) are well known to be at higher risk for acute myocardial infarction; however, the outcome after a cardiac event, in this patient population, remains unclear. Our objective was to examine the in-hospital mortality in patients with SLE and RA presenting with acute myocardial infarction (AMI) compared to the general population.
Methods: The National Hospital Discharge Survey (NHDS) is an annual national probability sample survey of discharges from non-federal, general, and short-stay hospitals located in the 50 States and the District of Columbia. It has been conducted continuously by the Centers for Disease Control and Prevention’s National Center for Health Statistics (NCHS) since 1965. Utilizing codes from the International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM), we identified 51,628 adult patients in the NHDS admitted with an acute myocardial infarction in the period between 2001 and 2009. Among those, 405 patients also had a diagnosis of RA or SLE.
Results: The in-hospital mortality for patients with acute myocardial infarction and CTD was 3.7% compared to 8.2% in patients without CTD (p<0.001). After adjusting for demographic and clinical variables using logistic regression analysis, CTD remained an independent predictor of lower in-hospital mortality. (p=0.01, OR 0.50; 95% CI 0.29 - 0.85).
Conclusion: Patients with connective tissue disease admitted with acute myocardial infarction have a lower in-hospital mortality compared to other acute myocardial infarction patients.
- © 2013 by American Heart Association, Inc.