Abstract 11177: Frequency and Predictive Value of Abnormal Ankle Brachial Index (ABI) Score in Patients Needing Coronary Interventions
Backgrounds: Coronary artery disease (CAD) and peripheral arterial disease (PAD) are significant manifestations of atherosclerotic vascular disease, one of the major causes of morbidity and mortality worldwide. We aimed to investigate whether an abnormal ABI can predict CAD with ≥ 70% stenosis in the high atherosclerotic risk population like veterans.
Methods: A retrospective two group comparison design was used to investigate the differences in Ankle-Brachial Index (ABI) readings of patients who underwent diagnostic cardiac catheterization. A total of 167 patients were selected from the Cardiology Repository Data Registry (a) who underwent elective coronary angiography between October 2010 and September 2011; and (b) whose ABI were measured during their pre-evaluation visit with the calculated ABI not greater than 1.21 to exclude cases with abnormal ABI due to a non-atherosclerotic disease process. Patients were divided into two groups, those with essentially normal coronary arteries or with coronary stenosis < 70% (Group A: Non-CAD group) and those with significant coronary stenosis ≥70% needing coronary revascularization (Group B: CAD group).
Results: All 167 subjects were male and the average of their age was 76 years (range: 45- 87). Baseline characteristics were generally comparable among the two groups. This study showed that patients with severe CAD ≥70% stenosis (Group B) are 4.7 times more likely to have abnormal ABI ≤ 0.90 than patients without severe CAD (Group A) (Chi-Square, p =0.001). The frequency of abnormal ABI score also increases with the number of major epicardial vessel with ≥ 70% stenosis (Chi-Square, p =0.007). Using generalized logistic regression, the ABI score was predictive for the presence of significant CAD, independent of CV risk factors and cardiac stress test (p < 0.023).
Conclusions: This study showed a significant relationship between PAD (diagnosed by ABI ≤ 0.90) and significant CAD (≥70% stenosis). Moreover, it suggested that an abnormal ABI is predictive of CAD with ≥70% stenosis requiring coronary revascularization.
- © 2013 by American Heart Association, Inc.