Abstract 10990: The Relationship Between BMI and Incident Hypertension is Selectively Associated With Visceral Adipose Tissue: Observations From the Dallas Heart Study
Background: Obesity has been linked to the development of hypertension, but whether total adiposity, or association with site-specific fat accumulation, underpins this relationship is unclear.
Methods: Normotensive participants [defined as those with blood pressure (BP) < 130/85 based on the average of three sequential readings and not taking BP medications] enrolled in the Dallas Heart Study between 2000-2002 were followed for a median of seven years for the development of incident hypertension (BP ≥ 140/90 or initiation of BP medications). Visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) were quantified by MRI and hepatic triglyceride content (HTGC) by 1.5-T 1H-magnetic resonance spectroscopy. Multivariable relative risk regression was performed to test the association between individual fat depots on incident hypertension, adjusting for traditional risk factors and BMI.
Results: Of the 728 participants (median age, 40 years; 55% female; 60% non-white; median BMI, 27 kg/m2), 176 (24%) developed hypertension. In multivariable analysis adjusting for clinical risk factors, BMI was significantly associated with incident hypertension [relative risk (RR) 1.04; 95% CI, 1.04-1.22 per 5 kg/m2]. However, when VAT and SAT were added to the model, VAT was the only fat parameter independently associated with incident hypertension (RR 1.26; 95% CI, 1.07-1.49, per 1 kg), while BMI and SAT were not (Table ).
Conclusions: To our knowledge, these data from a large, multiethnic probability-based population cohort are the first to show that the long-held relationship between BMI and the development of hypertension are specifically associated with visceral adiposity. Additional studies will be needed to elucidate the mechanisms behind this association.
- © 2013 by American Heart Association, Inc.