Abstract 10931: FGF23 Concentration is Associated With Left Ventricular Hypertrophy and Reduced Left Ventricular Ejection Fraction in Cardiology Inpatients
Background and objectives: Fibroblast growth factor (FGF)-23 plays a crucial role in phosphate homeostasis through binding to FGF receptor with its co-receptor, Klotho. Recent studies suggested that FGF23 may be associated cardiac hypertrophy. We have investigated the association between serum concentrations of FGF23 and Klotho (α-Klotho) and cardiac hypertrophy and left ventricular function.
Methods: Serum levels of FGF23 and α-Klotho were determined by enzyme-linked immunosorbent assay. Left ventricular mass (LVM) was calculated according to the equation proposed by Devereux et al., and LVM index (LVMI) was obtained by dividing it by body surface area. Left ventricular ejection fraction (LVEF) was assessed using modified Simpson’s method via apical 4-chamber view. We also assessed the relationship between these cardiac parameters with other calcium-phosphate metabolism-related parameters; corrected calcium, inorganic phosphate (IP), intact parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D.
Results: Total of 102cardiology inpatients was enrolled in the current study. Univariate analysis showed that log-transformed FGF23, designated log(FGF23), was significantly associated with LVEF and LVMI with a standardized correlation coefficients of -0.35 (P<0.001) and 0.25 (P<0.05), respectively. On the other hand, α-Klotho did not have significant association with LVEF or LVMI. Log(FGF23) had a significant correlation with estimated glomerular filtration rate (eGFR),log(α-Klotho) and log(IP). After entering age,sex, systolic blood pressure, eGFR, log(α-Klotho), and all above-mentioned alcium-phosphate metabolism-related parameters as covariates, log(FGF23) remained to be significantly associated negatively with LVEF and positively with LVMI with standardized correlation coefficient of -0.32 (P<0.001) and 0.27 (P<0.01), respectively.
Conclusions: In cardiology inpatients, higher FGF23 concentrations were associated with lower cardiac systolic function and greater left ventricular mass. Whether therapies modulating serum FGF23 levels will change these cardiac parameters awaits further investigation.
- © 2013 by American Heart Association, Inc.