Abstract 10889: Serum Immunoglobulin G4 Level is a Useful Marker for Aortic Wall Remodeling
Objective: Immuno-inflammatory process may underlie cardiovascular remodeling. Although immunoglobulin G4 (IgG4)-related disease has been suggested to manifest as cardiovascular disorders such as chronic periaortitis, it remains unclear how IgG4-related immuno-inflammation affects subclinical stages of aortic remodeling. The relationship between serum IgG4 levels and aortic wall area was analyzed.
Methods: Aortic wall area was measured in 340 patients (192 males; mean age, 68.6 ± 9.8 years) who underwent 320-row cardiac computed tomography (CT) without previous surgery of ascending aorta. Among them, 192 patients (56.5%) were diagnosed to have coronary artery disease (CAD) by cardiac CT. We also calculated calcification volume of ascending aorta.
Results: Aortic wall area was significantly larger in patients with CAD (184 mm2, interquartile range [IR] 167-201) than in those without (176 mm2, IR 153-198, P<0.05). Aortic calcification volume was also statistically greater in patients with CAD (101 mm3, IR 3-468) than in those without (8 mm3, IR 0-132, P<0.001). Aortic wall area had a significant positive association with aortic calcification volume (R=0.213, P<0.001). Serum levels of IgG4 were significantly associated with aortic wall area (R=0.113, P<0.05), but not with aortic calcification volume (R=0.025, P=NS). In logistic regression analysis using age, gender, body mass index, CAD, calcification of ascending aorta, and estimated glomerular filtration rate (eGFR) as covariates, the fourth quartile of IgG4 (≥54.3 mg/dL) was a significant predictor of aortic wall area of median or greater (≥182 mm2) with an odds ratio of 1.82 (95% confidence interval 1.03-3.21).
Conclusions: Serum levels of IgG4 were significantly associated with aortic wall area, and this relationship was, at least in part, independent of aortic calcification. These findings suggest that immuno-inflammatory process may play a role in aortic wall remodeling.
- © 2013 by American Heart Association, Inc.