Abstract 10837: Prognostic Value of Right Ventricular Function Assessed by Magnetic Resonance Imaging in Patients With Interstitial Pneumonia
Objective: Cardiac magnetic resonance imaging (MRI) allows for accurate and non-invasive assessment right ventricular (RV) volume and function. The presence of pulmonary hypertension (PH) is important prognostic marker in patients with interstitial pneumonia (IP). We investigated the prognostic importance of RV function by cine MRI in patients with IP.
Materials and methods: Thirty-five patients with IP were prospectively enrolled in this study. We performed cine MRI to assess the RV ejection fraction (RVEF). Presence or absence of pulmonary hypertension (PH, mean pulmonary arterial pressure >25mmHg) was evaluated by right heart catheterization (RHC). RV dysfunction was defined as RVEF <48% (lower quartile) by cine MRI.
Results: During a median follow-up of 14.4 months, 4 severe events (2 deaths, 1 exacerbation of dyspnea requiring admission, 1 unstable angina requiring revascularization) were observed in 8 patients with impaired RVEF by MRI. In 27 patients with preserved RVEF by MRI, 1 death was observed during follow-up period. Kaplan-Meier curves demonstrated a significant difference in event-free survival between two groups in severe events (annual event rate, 61.0% and 4.0%, respectively; log-rank test, p= 0.003). PH was detected in 8 patients (23%) by RHC. Multivariate Cox proportional hazard analysis showed that presence of PH by RHC and RV dysfunction by MRI were independent predictors of severe events (presence of PH by RHC, hazard ratio [HR]: 13.01, 95% confidence interval [CI]: 1.352-125.3, p=0.026, RV dysfunction by MRI, HR: 13.67, 95% CI: 1.5-124.6, p=0.020).
Conclusions: The results in the present study suggest that impairment of RV systolic dysfunction calculated by MRI was independent prognostic marker in patients with IP.
- © 2013 by American Heart Association, Inc.