Abstract 10734: Association Between Fetuin A and Geriatric Sarcopenic Heart Failure: Echocardiographic Survey From Tianliao Old People (TOP) Study
Aims: Sarcopenia is an aging condition involving low muscle mass and low muscle function. Fetuin A (FetA), has recently been reported to be as a factor for body composition remodeling. We hypothesized that FetA functions in sarcopenic congestive heart failure (S-CHF) via the diastolic or systolic dysfunction process.
Methods and Results: We enrolled 541 elderly (≥ 65 years) patients. Their medical history, serologic data, and echocardiographic parameters were obtained. S-CHF was defined two criteria: sarcopenia and systolic dysfunction. Ninety-two (17%) patients (mean ± standard deviation (SD): 80.2 ± 5.9 years; male: 34.7%) were diagnosed with sarcopenia; 23 of them (25%) met the S-CHF criteria. Patients with S-CHF showed reduced systolic heart function (LVEF: 68.4 ± 8.6% vs. 64.2 ± 9.3%, p = 0.007), higher end-diastolic pressure (E/E′ 7.5 ± 2.1 vs. 10.3 ± 4.4, p = 0.001) and a higher FetA level (621.1 ± 140.7 vs. 697.3 ± 179 μg/ml, p = 0.0001); they also had a higher FetA level than did those with sarcopenia but without CHF (S-NCHF) (664.3 ± 163.8 vs. 788.2 ± 170.2 μg/ml, p = 0.0001). In the group without sarcopenia (NS), FetA levels were similar regardless of systolic function (620.5 ± 142.2 vs. 604.9 ± 104.3 μg/ml, p > 0.05) (Figure). Multivariable logistic regression showed that older age, impaired diastolic function, and higher FetA levels were significantly associated with S-CHF.
Conclusions: FetA was significantly higher in elderly patients with sarcopenia, which was associated with impaired diastolic and systolic functions. This implies a link between FetA and the sarcopenic heart.
Key words: Sarcopenia, Heart failure, Fetuin A, Diastolic dysfunction, Geriatric
- © 2013 by American Heart Association, Inc.