Abstract 10707: Impact of Coronary Artery Spasm on Development of New-onset Diabetes Mellitus in Asian Population
Background: There have been several reports that endothelial dysfunction predicts type 2 diabetes. It is still controversial whether a coronary artery spasm (CAS) is a risk factor of new-onset diabetes mellitus (DM), especially in Asian population.
Methods: We investigated the 4,231 patients (pts) who had HbA1C level < 6.0% and fasting glucose level < 100 mg/dL (CAS group=303 and control group=3,928). CAS was defined as transient coronary artery narrowing 70% or more by acetylcholine provocation test. To adjust confounders including age, gender, hypertension, hyperlipidemia, chronic kidney disease, hyper/hypo-thyroidism, lipid profile, beta-blocker, diuretics, a propensity score matched analysis was performed. The primary end-point was the cumulative incidence of new-onset DM (HbA1C level > 6.5% or fasting glucose level > 126 mg/dL). Also, multivariable cox-regression analysis adjusted by aforementioned variables was performed to determine the impact of CAS on the incidence of new-onset DM.
Results: Mean follow-up duration was 908±558 days in all-pt group, and 805±579 days in PSM group. Baseline characteristics were similar between the two groups in PSM cohort. In Kaplan-Meyer curve, there was no difference between the two groups (p=0.937, figure A). Also, in cox-regression analysis performed in all pts, presence of CAS was not associated with the increased incidence of primary end-point (figure B).
Conclusions: In our study, there was no clear association between CAS and new-onset DM in a series of cardiovascular pts in Asian population.
- © 2013 by American Heart Association, Inc.