Abstract 10406: Impact of DASH Diet on Endothelial Function in Heart Failure Patients
Background: Endothelial dysfunction has been recognized as a pathophysiologic mechanism in the progression of heart failure (HF). Much of current pharmacotherapy of HF focuses on improving vascular function but little attention has been paid to ability of dietary approaches to improve endothelial function. We, therefore, sought to examine the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on endothelial function in patients with symptomatic HF.
Methods: Forty chronic Stage C, functional class I to III, HF patients were randomized to either be on a DASH diet regimen or follow the general HF dietary recommendations for 1 month. Age was 40 to 84 (mean 64) years; 22 were men. Mean ejection fraction was 42±15%. To assess endothelial function, large and small arterial elasticity (LAE, SAE) at rest were obtained using the pressure pulse contour analysis technique with the Cardio-Vascular Profiling Instrument model CR-2000 (Hypertension Diagnostics, Inc., Eagan, MN). Data collected included exercise capacity as measured by 6-min walk test, weight and DASH diet index score for compliance.
Results: Patients tolerated the DASH diet regimen without complications. Average DASH diet index score was 6.8/11.The net change in LAE at 1 month was significantly improved in the DASH group when compared to the control group (p < 0.05). Additionally, patients in the DASH group had improved 6-minute walk distance at 1 month compared to their control counterparts (p < 0.05). There was also a trend towards weight loss (-2.5kg) in the DASH group, and weight gain (+0.8kg) in the control group at 1 month. (p <0.05)
Conclusion: At one month, compared to dietary controls, patients who followed a DASH diet had improved large artery compliance and 6 minute walk times. Longer term evaluations are in progress. The DASH diet may potentially be an important adjunctive therapy for patients with symptomatic HF.
- © 2013 by American Heart Association, Inc.