Abstract 10335: Influence of Post-smoking Cessation Weight Gain on Serum a1-antitrypsin-low Density Lipoprotein Levels
Background & Aims: Weight gain often occurs after smoking abstinence, and such weight gain is thought to contribute to the worsening of glucose tolerance. We previously reported that serum levels of α1-antitrypsin-low density lipoprotein (AT-LDL), oxidatively modified LDL that promotes arteriosclerosis, are increased in current smokers and rapidly decreased after smoking cessation. The present study investigated the influence of post-smoking cessation weight gain on AT-LDL, an atherogenic cardiovascular marker.
Methods: We evaluated 186 patients (132 males and 54 females) who visited our outpatient clinic for smoking cessation, and successfully achieved smoking abstinence. We performed gender-adjusted regression analysis for the rate of BMI increase from the beginning of cessation to 3 months after the beginning. We also performed multivariate analysis to investigate factors that determine BMI increase after smoking cessation. Furthermore, we determined serum levels of AT-LDL by ELISA.
Results: The %BMI increase at 3 months after the initial consultation were 1.5%, and the increase were significantly correlated with serum triglyceride (p=0.0006, β a=0.260) and HDL-C (p=0.0386, βa=-0.168) levels, daily cigarette consumption (p=0.0385, βa=0.154) and the Fagerström Test for Nicotine Dependence (FTND) score (p=0.0060, βa=0.203) at the initial consultation. Stepwise multivariate analysis demonstrated that FTND score was the strongest factor that determines BMI increase after smoking cessation. The serum levels of AT-LDL at 3 months after the start of smoking cessation therapy significantly decreased (AT-LDL:2.7 to 2.2 μg/ml, p< 0.01) in the group with BMI increase less than the average (1.5%). However, in the group with BMI increase more than 1.5%, the AT-LDL levels did not decrease (AT-LDL:2.5 to 2.4 μg/ml, NS). Pre-to post-cessation change in the AT-LDL levels had a significant correlation with the change in the BMI (r=0.258, p=0.013).
Conclusions: Smoking patients with high FTND score are more likely to gain weight after smoking cessation. The results also suggest that weight gain after smoking cessation perturbs ameliorating an atherogenic cardiovascular biomarker, AT-LDL.
- © 2013 by American Heart Association, Inc.