Abstract 10300: Impact of Chronic Kidney Disease on the Presentation Symptoms and In-Hospital Outcomes of Patients With Atrial Fibrillation: From a 20-Year Registry
Objectives: The aim of this study was to identify whether patients with chronic kidney disease (CKD) have different presentation symptoms and in-hospital outcome compared to patients with normal kidney function when presenting with atrial fibrillation (AF) in a real-world population.
Methods: Retrospective analysis of all patients hospitalized with AF in the State of Qatar from 1991 through 2010 was made. Clinical characteristics, management, and outcomes of AF patients were compared according to the presence or absence of CKD.
Results: During the 20-years period 3850 patients were hospitalized for AF; 182 with CKD and 3668 with normal kidney function. Patients with CKD had significantly more prevalence of hypertension, diabetes mellitus dyslipidemia, underlying coronary artery disease and heart failure. They were significantly more likely to present with shortness of breath and chest pain than palpitation which was more likely in patients without CKD [table 1]. In-hospital stroke and mortality rates were significantly higher in CKD patients (2.2% versus 0.3%, 12.1% versus 3.8% respectively, p= 0.001). In multivariate analysis of predictors of in-hospital mortality, CKD was an independent predictor of in-hospital mortality (OR 4.03, 95% C.I. 1.43 - 11.37, P= 0.008) [table 2].
Conclusions: our study demonstrates that CKD patients hospitalized for AF differ considerably in the presentation symptoms and have worse in-hospital outcome that is independent from other co-morbidities which are also more prevalent in this unique group.
- © 2013 by American Heart Association, Inc.