Abstract 10274: Increased Cardiovascular Risk is Associated With Outward Remodeling of the Thoracic Aorta
Introduction: Glagov documented outward remodeling of coronary arteries with cardiovascular risk but it is unknown if increased cardiovascular risk (CV) is associated with remodeling of larger vessels such as the thoracic aorta. We assessed the association between CV risk factors, global risk and thoracic aorta dimensions in middle-aged adults free of clinical aortic diseases who were part of the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Method: Multislice computer tomography was used to measure the ascending and descending thoracic aorta cross sectional area in 1197 CARDIA participants. The ascending and descending thoracic aorta area were measured on non-contrast enhanced images using 0.5-0.6mm slices reformatted to provide true cross sections perpendicular to the vessel centerline, 3 D Slicer® [ROI pixel count multiplied by unit pixel area]. General linear modeling was used to assess the associations.
Results: 1197 participants with mean age 49.9 ±3.6 yrs, 52.9% blacks, 45.6% males, BMI 30.5 ±7.1 kg/m2, LDL-C 110.3 ±33.5 mg/dL, HDL-C 57.3 ±17.4 mg/dL, 11.1% diabetics, 39.3% former/current smokers and 35.4% had hypertension. The means (SD) for ascending and descending thoracic aorta areas were 827.9 ±179.0 and 458.0 ±88.4mm2 respectively. Ascending and descending thoracic aorta areas were associated with CVD risk factors such as hypertension, diabetes mellitus and smoking status. In our multivariable model, those with hypertension had larger aortic areas than those without hypertension (Table A). Thoracic aortic areas were also associated with lifetime CV risk (Table B) and CV risk burden (Table C).
Conclusions: Age, race, gender and height adjusted ascending and descending thoracic aorta area are associated with cardiovascular risk factors, risk burden and global CV risk suggesting that there is outward remodeling of the thoracic aorta with CV risk. Adjusted thoracic aorta area may be a marker for global cardiovascular risk.
- © 2013 by American Heart Association, Inc.