Abstract 10146: Changes in Left Ventricular Geometry in a Normal Population Over Two Decades
Obesity and overweight have become major health issues in developed societies during the last 20 years. Obesity is associated with hypertension and left ventricular (LV) hypertrophy, but the impact of lesser degrees of overweight on LV geometry in the normal population has not been defined. We hypothesized that the average increase in body size of the population over the last 20 years will be associated with adverse changes in LV geometry. We measured LV geometry by echocardiography in two triennial cohorts of patients, aged 21 to 60 years: 1988-1990 (n=664) and 2007-2009 (n=1148). All patients with normal echocardiograms in each cohort were included and body mass index (BMI, kg.m-2) was recorded at time of study. Diastolic LV cavity dimensions (LVED) and septal and posterior wall thickness (IVS, LVPW) were measured (American Society Echocardiography criteria), and relative wall thickness (RWT) and LV mass were calculated as RWT = (IVS + LVPW)/LVED and LV Mass = (0.8x(1.04x([IVS+LVPW+LVED]3 [[Unable to Display Character: –]] [LVED]3)) + 0.6g) respectively. Data comparisons between cohorts according to age and gender were by factorial ANOVA (SPSS Statistics, IBM Co). Increased BMI in young and middle aged adults during last 20 years is associated with an increase in absolute LV wall thickness and LV mass, with increased RWT consistent with concentric hypertrophy. These changes in LV geometry were more evident in males than in females. Increases in LV mass were proportional to change in body size. In conclusion, the absolute normal range for LV wall thickness and mass has shifted to higher values in the general population, reflecting increases in body size.
- © 2013 by American Heart Association, Inc.