Abstract 10102: Arterial Stiffness is Associated With Telomere Length and Glucose Metabolism
Arterial stiffness is one of the most prominent features of arterial aging. It has been shown a strong association of arterial stiffness with impaired glucose regulation. Leukocyte telomere length is a systemic aging biomarker and an independent predictor of cardiovascular diseases. We assessed the hypothesis that telomere length and glucose metabolism are the main predictors of arterial stiffness.
The aim of our study was to determine whether telomere length and glucose metabolism indicators explain variability in arterial stiffness, evaluated by measuring aortic pulse wave velocity (PWV).
Methods: Serum fasting glucose, insulin, glycosylated haemoglobin (Hb1Ac) were determined using routine laboratory methods. HOMA-IR was calculated as fasting insulin(mU/ml)x fasting glucose(mmol/l)/22,5. Telomere length was determined by quantitative polymerase chain reaction. PWV was measured with the help of SphygmoCor (AtCor Medical).
Results: The study group included 150 subjects mean age 51.3 ±12.3 years, free of known cardiovascular diseases. 20 subjects had type 2 diabetes mellitus. PWV was significantly correlated with age (r=0,5221, p=0,0001), fasting glucose(r=0,3532, p = 0,0012), HOMA-IR (r=0,2390, p=0,0197), Hb 1Ac (r=0,2614, p=0,0023). A significant negative correlation was identified between PWV and telomere length (r=-0,3125, p=0,0022). Through multiple linear regression analysis, PWV was found to be independently and positively associated with age,fasting glucose, Hb1Ac. PWV was independently and negatively associated with telomere length (see the table).
In all subjects age, telomere length, fasting glucose, Hb1Ac predicted 43% of the variance in PWV (p-0,0001)
Table. Stepwise linear regression analysis of PWV on age, telomere length, fasting glucose, Hb1Ac.
Conclusions: Telomere length along with indicators of glucose metabolism mainly determine arterial stiffness.
- © 2013 by American Heart Association, Inc.