Letter by Sikkel et al Regarding Article, “Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy”
To the Editor:
We read the article by Coppini et al1 with great interest. The insight that they provide into the electrophysiological phenotype of the cardiomyocyte in hypertrophic cardiomyopathy was made all the more convincing because of their use of robust hierarchical statistical methodologies for significance testing.
Statistical significance testing is now almost ubiquitous in basic cardiovascular science studies and allows decisions to be made on the basis of the data collected and their critical and analytic appraisal. However, one important factor that is commonly ignored in otherwise first-class research is the hierarchical …