Abstract P447: Associations between Multiple Lifestyle Factors and Glycated Hemoglobin in the Singapore Chinese Health Study
Studies are limited, especially in Asian populations, on the association between multiple behavioral risk factors for cardiovascular disease (CVD) and red blood cell glycated hemoglobin (HbA1c), a strong predictor of type 2 diabetes and CVD. We evaluated the association of multiple behavioral risk factors and HbA1c in the Singapore Chinese Health Study, including 5,194 men and women 48-81 years of age at the time of the blood draw (1999-2004), when they reported never having been diagnosed with diabetes. Self-reported chronic diseases, demographic factors, height, weight, and lifestyle were assessed by questionnaire at baseline (1993-98). We created a summary index of 5 protective behavioral risk factors including physical activity (high v. low), principal components-derived vegetable and soy dietary pattern (high v. low), cigarette smoking (no v. yes), sleep duration (6-7 hr/wk v. more or less), and alcohol intake (women: up to 1 drink/day, men: up to 2 drinks/day v. more or none). Body mass index (BMI) was categorized into four groups, coded from 0 to 3 for increasing level of protection ≥26 kg/m2, 24-26, 22-24, and <22. The index ranged from 0 (no protective factors) to 7 when BMI categories were included, and from 0 to 4 without BMI included. The table shows adjusted least squares means of HbA1c (%) from multivariable linear regression including the covariates age, sex, education, and dialect. The index demonstrated a graded inverse association with HbA1c, and this association remained significant when BMI was removed from the index and modeled as a covariate. More studies are needed to fully examine HbA1c as a potentially important mediator between a variety of behavioral and anthropometric factors and risk of diabetes and cardiovascular diseases in different ethnic groups.
- © 2013 by American Heart Association, Inc.