Abstract P444: Height is Associated with a Lower Risk of Diabetes Melitus in the Physicians' Health Study
Background: Chronic inflammation during childhood growth may adversely influence the maximum achievable adult height, suggesting that adult height could be a surrogate for early childhood inflammatory processes. Although inflammation plays a role in the pathogenesis of diabetes (DM), no previous study has assessed the association between height and the risk of DM.
Objective: To test the hypothesis that adult height is inversely associated with incident DM in the Physicians’ Health Study (PHS).
Method: Current analyses are based on 24,460 PHS participants that were free of DM at baseline. Adult height was self reported at baseline and DM was ascertained via follow-up questionnaires and validated in a subsample by review of medical records. We used Cox proportional hazard model to estimate hazard ratios.
Results: Mean age of the participants was 53.6 ±9.4years, and mean height was 178.4cm. During a mean follow up of 22 years, 2403 men (11.2%) developed DM. In a multivariable cubic spline model controlling for age, waist circumference, lifestyle factors (smoking, vigorous exercise), dietary factors (red meat, fish, breakfast cereals, eggs, and alcohol intake) and metabolic factors (treatment of hypercholesterolemia, hypertension), height was inversely associated with incident DM (p for linear trend 0.011, Fig. 1). Hazard ratio per one standard deviation higher height was 0.92 (95% CI: 0.89-0.96).
Conclusion: Our data showed an inverse association of adult height with incident DM in US male physicians. Replication of these findings and exploration of biologic mechanisms are warranted.
- © 2013 by American Heart Association, Inc.