Abstract P419: Association Between Physical Activity and Risk Factors for Metabolic Syndrome in a Sample of HIV+ Men and Women Currently Taking Antiretroviral Therapy
Background: Metabolic Syndrome (MetSyn) is a strong predictor of type 2 diabetes and cardiovascular disease (CVD). Recent data show that people living with HIV/AIDS (PLWHA) are at a greater risk of CVD, which could possibly be explained by an increased prevalence of MetSyn as a result of the metabolic disturbances known to be associated with antiretroviral therapy (ART). The purpose of this study is to examine the relationships among physical activity (PA) and risk factors for MetSyn in a sample of HIV+ adults currently taking ART.
Methods: A total of 32 males and 38 females living with HIV and currently taking ART were enrolled in an ongoing PA intervention aimed to reduce risk factors for CVD. Clinical assessments included measures of resting blood pressure (BP), waist circumference, height, weight, PA levels via accelerometer, and a fasted blood draw. Inactivity was defined as measured activity < 3 metabolic equivalents (METS) or if the person was sedentary, whereas moderate to vigorous PA was defined as any activity ≥ 3 METS. Accelerometer data was considered valid if the participant had a total on-body time of at least 10 hours a day for 4 days. Levels of PA were divided into 4 quartiles (Q1=0-40 mins of PA; Q2=40-80 mins; Q3=80-160 mins; Q4≥160mins). A one-way ANOVA was used to determine differences between quartiles.
Results: Waist circumference was significantly lower across PA quartiles (p < 0.001). A similar pattern was observed in fasting glucose levels; however the results were not significant. Pearson correlation showed a significant association between PA and waist circumference (r = - 0.526; p < 0.001), but not BP or fasting glucose. Although fasting glucose was not significantly associated with PA, the Pearson correlation did show a significant association between inactivity and fasting glucose (r = 0.433; p = 0.019).
Conclusions: These data show that greater amounts of PA are significantly associated with a smaller waist circumference for PLWHA who currently took ART. A significant relationship was also observed among inactivity and fasting glucose. In conclusion, routine PA can be beneficial in helping PLWHA reduce waist circumference and decrease sedentary time ultimately leading to a reduction in fasted glucose levels. This in turn would help PLWHA self-manage known risk factors for MetSyn, thus reducing their risk of CVD.
- © 2013 by American Heart Association, Inc.