Abstract P411: Who Uses Multivitamins? A Cross-sectional Study in the Physicians’ Health Study
Background Multivitamins are the most commonly taken supplements by US adults. We sought to examine the prevalence of self-reported multivitamin use in the Physicians’ Health Study (PHS) cohort and its association with various lifestyle, clinical, and dietary factors to improve our understanding of who tends to use multivitamins. This is particularly important given the recent results of the PHS II, a trial that investigated the long-term effects of a daily multivitamin on the risk of cardiovascular disease (CVD) and other endpoints.
Methods We performed a cross-sectional study of self-reported multivitamin use and various coronary risk factors among 20,570 men from the PHS cohort starting in 1997. Information on lifestyle and clinical factors were collected from a baseline enrollment questionnaire, while information on supplement use and dietary factors were assessed through a food-frequency questionnaire. We considered 3 definitions of multivitamin use: (1) overall, (2) taking multivitamins with other vitamin/mineral supplements, and (3) only taking multivitamins. We used logistic regression to calculate multivariate odds ratios and 95% confidence intervals to examine the likelihood of taking multivitamins for various coronary risk factors.
Results The overall prevalence of multivitamin use was 35%. In multivariate models (Table 1), men who took multivitamins compared with those who did not tended to be older, leaner, past smokers, and more physically active. Multivitamin users were also more likely to have a history of high cholesterol and hypertension. Finally, men taking multivitamins also tended to consume more fruits and vegetables.
Conclusion Self-reported multivitamin use may be an indicator of healthy behaviors, but was also positively associated with intermediate cardiovascular endpoints. Taken together, these results provide important information for the interpretation and generalization of observational studies of multivitamins and CVD as well as the recent findings from the PHS II trial.
- © 2013 by American Heart Association, Inc.