Abstract P401: Plasma N-3 Polyunsaturated Fatty Acids are Associated with Worse Systolic Function and Heart Rate
Introduction The number of people with heart failure is expected to rise in the future. Higher plasma levels of n-3 polyunsaturated fatty acids (PUFAs) may play a role in the loss of heart function and prevention of heart failure.
Hypothesis We hypothesize that lower plasma concentrations of total and individual n-3 PUFAs are associated with less favorable echocardiographic measures and heart rate, both cross-sectionally and after eight years of follow-up in an older population in the Netherlands.
Methods We used data from the prospective, population-based Hoorn Study, mean age 68.6±6.7 years, 50.7 % female, with oversampling for impaired glucose regulation. Cross-sectional data were available for 620 participants and longitudinal data for 336. We performed linear regression analyses to determine associations of n-3 PUFAs quartiles with left ventricular (LV) ejection fraction, LV mass index, left atrial volume index and heart rate and adjusted for potential confounders. We also investigated associations of individual n-3 PUFAs with cardiac measures.
Results In a multivariable model, cross-sectional analysis showed that lower total n-3 PUFAs were significantly associated with lower LV ejection fraction; regression coefficient -1.9 (95% CI -3.7, -0.0) and higher heart rate 3.0 (95% CI 0.8, 5.2) (Figure 1). Plasma n-3 PUFAs were not associated with LV mass index and left atrium volume index. The individual n-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid were significantly associated with LV ejection fraction and heart rate. Longitudinal associations were not significant for any of the cardiac measures. Survival bias cannot be excluded since participants with only baseline data had higher prevalence’s of type 2 diabetes, prior CVD and/or hypertension.
Conclusion In conclusion, this study indicated that lower plasma total n-3 PUFAs were cross-sectionally associated with worse systolic function and heart rate. The study results provide some evidence for a potential role of n-3 PUFAs in heart function.
- © 2013 by American Heart Association, Inc.