Abstract P389: Low Total Testosterone is Associated with Left Ventricular Diastolic Dysfunction in a Large Group of Asymptomatic Middle-Aged Men
Background: Testosterone is linked with cardiovascular mortality among healthy men between the ages of 40-79. Studies have shown that testosterone affects left ventricular (LV) performance. In addition, endogenous testosterone can enhance vasodilation. Currently, there are few studies that have examined the relationship between total testosterone (TT) and LV diastolic function in a healthy population. We aim to investigate whether a relationship exists between total testosterone (TT) levels and left ventricular diastolic dysfunction (LVDD) in a large population of asymptomatic middle-aged men.
Methodology: We evaluated 1533 male participants in the Law Enforcement Cardiac Screening Program (LECS) from 2008 to 2010. Subjects underwent evaluation with an echo Doppler study. Parameters included peak mitral inflow velocities at early (E) and late (A) diastole, transmitral E/A ratio and tissue Doppler imaging (TDI) of the left ventricular (LV) septum in the apical four chamber view. LVDD was defined as LV E/A < 1, or LV TDI e’/a’ < 1 or E/e’ ratio > 12. Low TT was defined as TT of < 300 ng/dL.
Results: TT is associated with LVDD in men younger than 50 years of age. Out of 607 subjects with low TT, 59.1% had LVDD, compared to 49.4% of subjects with TT > 300 ng/dl (p < 0.0001). When adjusted for body mass index, self-reported diabetes mellitus and hypertension, ejection fraction 12mm, the association between Low TT and LVDD remained significant (p = 0.019).
Conclusion: We were able to show a significant association between low TT and LVDD. Low TT is a suitable independent indicator of diastolic dysfunction in males without overt cardiac symptoms. Clinicians are encouraged to include TT levels in middle-aged men as part of a routine cardiovascular risk assessment
- © 2013 by American Heart Association, Inc.