Abstract P382: Differential Distributions of Carotid-Femoral and Brachial-Ankle Pulse Wave Velocity with Age and Race: The ARIC Study
Background: Carotid-femoral PWV (cfPWV), a well-studied measure of central arterial stiffness is associated with cardiovascular disease and mortality. Brachial-ankle PWV (baPWV) is commonly used in Asian countries as a measure of peripheral arterial stiffness. Few studies have evaluated the population distributions of cfPWV and baPWV and the degree to which they may measure the same arterial characteristics.
Objectives: Characterize cfPWV and baPWV in a population of older adults by age, gender and race.
Methods: We analyzed 2,403 adults (1473 females; mean age 75 years) from the population-based Atherosclerosis Risk in Communities (ARIC) study who had data on cfPWV and baPWV, after excluding 763 individuals due to arrhythmias, 165 with BMI >40 kg/m2, and 300 with missing covariates of interest. Technicians used Omron VP-1000 plus system (Colin Co., Komaki, Japan) and followed a standardized protocol, to measure cfPWV and baPWV twice, and the results were averaged. The cumulative distributions of cfPWV and the right baPWV by age dichotomized at median, sex and race (African American (AA) and non-AA) were evaluated with the Kolmogorov-Smirnov test and the relationship between cfPWV and baPWV assessed by the Pearson correlation coefficient.
Results: The mean (SD) cfPWV and baPWV was 1159 (303) and 1736 (319) cm/sec. The empirical distribution function of both these measures was higher (p<0.001) among those 75 years and older than those younger than 75 years i.e., mean (SD) of cfPWV was 1229 (321) vs.1099 (274) cm/sec, respectively, and mean (SD) of baPWV was 1814 (328) vs. 1670 (295) cm/sec, respectively. The distribution function of cfPWV was higher among AAs (p<0.001) but the distribution of baPWV was not different by race (p=0.76). The mean (SD) in cm/sec for AA participants compared to non-AA participants for cfPWV was 1232 (335) vs. 1138 (290), and baPWV was 1725 (324) vs. 1740 (317). The distributions of cfPWV and baPWV did not differ by gender, p=0.21 and p=0.23, respectively. The mean (SD) cfPWV and baPWV among males was 1174 (305) and 1728 (318), and among to females was 1150 (302) and 1742 (320) cm/sec. Correlation analysis showed that cfPWV and baPWV were positively correlated, r=0.45, (p<0.001).
Conclusion: The distributions of cfPWV and baPWV were similar by gender but were different by age and by race. Despite having comparable measure of peripheral vascular stiffness, African Americans showed a higher degree of central vascular stiffness compared to non-African Americans. Our findings indicate that cfPWV and baPWV are correlated measures of arterial stiffness but likely reflect different aspects of segment-specific vascular impairment and cardiovascular risk.
- © 2013 by American Heart Association, Inc.