Abstract P381: Relations of Subclinical Measures of Arterial Stiffness and Pulsatility with Arterial Calcification in Men and Women
Introduction Arterial stiffness and calcification of the coronary arteries and aorta are each associated with cardiovascular disease (CVD) morbidity and mortality. We aimed to examine the relations of arterial stiffness and pressure pulsatility with arterial calcification.
Methods Framingham Heart Study Third Generation and Offspring cohort participants underwent applanation tonometry during 2002-2005 and 2005-2008, respectively, in order to assess carotid-femoral pulse wave velocity (CFPWV), a measure of arterial stiffness, and central pulse pressure (CPP). A subset of each cohort (n=1905 of 4028, 55%M, 45±6 yrs and n=657 of 2768, 43%M, 66±9 yrs, respectively) underwent multi-detector computed tomography (2002-2005) to assess presence and quantity of thoracic and abdominal aortic calcium (TAC, AAC) and coronary artery calcium (CAC). Multivariable-adjusted logistic regression models were used to relate tonometry measures to calcification measures in participants free of CVD.
Results Prevalent TAC, AAC, and CAC were seen in 5%, 35%, and 28% of the Third Generation and 46%, 78%, and 66% of the Offspring, respectively. In multivariable-adjusted logistic regression models, CFPWV and CPP were related to each calcification measure, with the strongest associations between CFPWV and TAC (TABLE). No effect modification by cohort or sex was seen.
Conclusions In this large cross-sectional study of community-dwelling individuals without prevalent CVD, strong relations were observed between increasing arterial stiffness and pressure pulsatility and presence of arterial calcification. Our findings highlight the association of abnormal hemodynamics with vascular calcifications. The mechanisms of these associations are likely bidirectional and deserve further study.
- © 2013 by American Heart Association, Inc.