Abstract P379: The Association of Sex Hormones with Carotid Artery Distensibility in Men and Women: Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Nowreen Haq MD, MPH, Dhananjay Vaidya MBBS, PHD, Susan R. Heckbert MD, PhD, Kiang Liu PhD, Pamela Ouyang MBBS
Introduction: We have previously shown that the association of aging with carotid artery distensibility coefficient (DC) differs between men and postmenopausal women. We therefore examined the association between endogenous sex hormones (SH) and DC in men and postmenopausal women in MESA.
Methods: B-mode ultrasound-measured carotid diameters and brachial pressures were obtained from 5761 participants (48% female, 38% white, 12% Chinese, 27% black, 23% Hispanic, 45-85 years) of the MESA baseline examination. We examined differences in DC by sex-specific quartiles of SH (bioavailable Testosterone [BioT, estradiol [E2] and Sex Hormone Binding Globulin [SHBG]) separately in men and women, adjusted for demographic and cardiovacular risk factors, using mixed models to adjust for blood pressures that are included in the calculation of DC.
Results: The table shows that higher BioT quartiles are significantly associated with greater DC in men, but lower DC in women. Higher E2 quartiles are associated with lower DC, but this trend is significant only in men. Higher SHBG quartiles are associated with higher DC only in women.
Conclusion: A relatively androgenic state has disparate associations with DC by sex, with more distensible carotids in men but less distensible carotids in women. Lower E2 levels in men, and higher SHBG levels in women are associated with a higher DC, and thus a better cardiovascular profile, consistent with what was shown for other cardiometabolic risk factors.
- © 2013 by American Heart Association, Inc.